Measuring the success of blinding in placebo-controlled trials: Should we be so quick to dismiss it?

Turning a blind eye: the success of blinding reported in a random sample of randomised, placebo controlled trials.

OBJECTIVE To examine the reporting and success of double blinding in a sample of randomised, placebo controlled trials from leading general medicine and psychiatry journals. METHODS Identification of placebo controlled, randomised controlled trials from prespecified general medical and psychiatric journals indexed on Medline between 1 January 1998 and 1 October 2001, from which a random sampl...

the impact of e-readiness on ec success in public sector in iran the impact of e-readiness on ec success in public sector in iran

acknowledge the importance of e-commerce to their countries and to survival of their businesses and in creating and encouraging an atmosphere for the wide adoption and success of e-commerce in the long term. the investment for implementing e-commerce in the public sector is one of the areas which is focused in government‘s action plan for cross-disciplinary it development and e-readiness in go...

Multicollinearity: What Is It, Why Should We Care, and How Can It Be Controlled?

Multicollinearity can be briefly described as the phenomenon in which two or more identified predictor variables in a multiple regression model are highly correlated. The presence of this phenomenon can have a negative impact on the analysis as a whole and can severely limit the conclusions of the research study. This paper reviews and provides examples of the different ways in which multicolli...

Erythema nodosum :what should we consider about it?

Should We Still Believe in Randomized Controlled Trials in Nephrology?

The randomized controlled trial (RCT) is the cornerstone upon which clinical decision-making is based. Pivotal RCTs in the nephrology area efficiently demonstrated the renoprotective effects of treatment with renin-angiotensin system inhibitors in patients with diabetic and non-diabetic proteinuric nephropathies. However, there is concern about the increasing cost, complexity and duration of cl...